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          • Proteins & Peptides ›
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          CD273 (B7-DC) Proteins

          CD273 (B7-DC) Human peptides and recombinant proteins are validated for use in the following applications: Blocking Assay, ELISA and Functional Assay. These proteins are expressed in CHO cells and E. coli. Available Product Grades: RUO. Gibco and Invitrogen proteins are some of the most... CD273 (B7-DC) Human peptides and recombinant proteins are validated for use in the following applications: Blocking Assay, ELISA and Functional Assay. These proteins are expressed in CHO cells and E. coli. Available Product Grades: RUO. Gibco and Invitrogen proteins are some of the most frequently published proteins. CD273 (B7-DC) Protein have... CD273 (B7-DC) Human peptides and recombinant proteins are validated for use in the following applications: Blocking Assay, ELISA and Functional Assay. These proteins are expressed in CHO cells and E. coli. Available Product Grades: RUO. Gibco and Invitrogen proteins are some of the most frequently published proteins. CD273 (B7-DC) Protein have been referenced in 2 publications which can be found in our reference library. Our Gibco brand includes SKUs from PeproTech™, acquired by Thermo Fisher Scientific. Browse all 3 proteins, including biologically active options. Not finding the exact protein, grade or size needed? Contact us to... CD273 (B7-DC) Human peptides and recombinant proteins are validated for use in the following applications: Blocking Assay, ELISA and Functional Assay. These proteins are expressed in CHO cells and E. coli. Available Product Grades: RUO. Gibco and Invitrogen proteins are some of the most frequently published proteins. CD273 (B7-DC) Protein have been referenced in 2 publications which can be found in our reference library. Our Gibco brand includes SKUs from PeproTech™, acquired by Thermo Fisher Scientific. Browse all 3 proteins, including biologically active options. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.

          Protein Information

          Programmed death-ligand 2 (PD-L2), or B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily that, along with programmed death-ligand 1 (PD-L1), acts as a ligand for programmed cell death protein 1 (PD-1). Though expressed primarily in dendritic cells, PD-L2 expression can be induced on a wide variety of immune and non-immune cells depending on the microenvironment. PD-L2 expression is particularly upregulated in the presence of Th2 cytokine, IL-4, as well as Th1 cytokines, TNF-alpha and IFN-gamma to a lesser degree. While generally expressed at lower levels compared to PD-L1, PD-L2 demonstrates a 2 to 6 times higher relative affinity to PD-1 than PD-L1. PD-1 and its ligands are referred to as inhibitory immune checkpoint molecules in that they provide useful negative feedback during physiological homeostasis. Ligation of PD-L2 or PD-L1 inhibits activation, proliferation, and cytokine secretion (e.g. IFN-gamma, IL-10) in T cells, ultimately dampening immune response. Conversely, studies have shown that PD-L2 can also stimulate T cell proliferation and cytokine production, even in PD-1-deficient T cells, suggesting additional receptors. Recent studies have concluded that PD-L2 also binds to a second receptor, repulsive guidance molecule b (RGMb), which was originally identified as a receptor for bone morphogenetic proteins (BMPs). RGMb is expressed in the central nervous system, as well as in macrophages, however, its role in immunity is only beginning to emerge. Interaction between PD-L2 and RGMb regulates the development of respiratory tolerance in the lung through BMP and/or neogenin signaling pathways. The naturally occurring human PD-L2 monomer consists of a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.

          Synonyms

          B7 dendritic cell molecule; B7DC; B7-DC; bA574F11.2; Btdc; Butyrophilin B7-DC; butyrophilin-like protein; CD273; F730015O22Rik; MGC124039; MGC124040; PD1 ligand 2; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; PDCD1L2; PDCD1LG2; Pdl2; PD-L2; Programmed cell death 1 ligand 2; programmed death ligand 2

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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

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          3 results
          Gibco
          Human PD-L2 Fc Recombinant Protein, PeproTech®
          Gibco
          Human PD-L2 Fc Recombinant Protein, PeproTech®
          Host
          Species
          Human
          Expression System
          CHO cells
          Product Grade
          Research Use Only
          Application
          ELISA Functional
          Price
          Special offer
          Online exclusive
          Online offer:
          Cat # 310-38-100UG
          Invitrogen
          Human CD273 (B7-DC) (aa 147-220) Control Fragment Recombinant Protein
          Invitrogen
          Human CD273 (B7-DC) (aa 147-220) Control Fragment Recombinant Protein
          Host
          Species
          Human
          Expression System
          E. coli
          Product Grade
          Research Use Only
          Application
          Ctrl BLOCK
          Price
          Special offer
          Online exclusive
          Online offer:
          Cat # RP-90599

          100 µL

          Invitrogen
          Human CD273 (B7-DC) Synthetic Peptide
          Invitrogen
          Human CD273 (B7-DC) Synthetic Peptide
          Host
          Species
          Human
          Expression System
          Product Grade
          Research Use Only
          Application
          Ctrl BLOCK
          Price
          Special offer
          Online exclusive
          Online offer:
          Cat # PEP-0464

          50 µg

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